|
|
|
| Clinical problems awaiting solution |
| Clinical problems for which we found no evidence to act upon. If you know of any good evidence, please write us at webmaster@ebpcenter.com. |
| Category |
Treatment
|
| Patients |
Patients with bipolar disorder, manic episode |
| Exposure |
valproate |
| Comparison |
placebo |
| Outcome |
Mania Rating Scale |
| EER |
@ |
| CER |
@ |
| NNT/NNH |
@ |
| Comments |
Because of the differential dropouts (25% on valproate and 50% on placebo), the LOCF results (50% response on valproate and 25% on placebo) is entirely compatible with the possibility that these two do not differ at all. |
| Reference |
Bowden CL et al (1994) Efficacy of divalproex vs lithium and placebo in the treatment of mania. JAMA 271: 918-924.
|
| Appraiser |
Dr Yumi Nakano |
| Lastappraised |
1/19/2004 |
|
From RCT into NNT
